Progut MUPS tablet: Progut MUPS tablet is indicated for the relief of heartburn and
other symptoms associated with gastro esophageal reflux diseases (GERD) and for
the healing of erosive esophagitis, a potentially serious condition associated with
GERD. It is also indicated in NSAID induced gastric ulcer and Zollinger-Ellison
syndrome. The FDA approved Esomeprazole is also indicated in combination with
Amoxicillin and Clarithromycin, for the eradication of Helicobacter pylori infection in
patients with duodenal ulcer disease.

Dosage & Administration


Gastroesophageal reflux disease (GERD)
Healing of erosive esophagitis20 mg or 40 mg Once daily for 4 to 8 weeks *Once daily for 4 to 8 weeks *
Maintenance of healing of erosive esophagitis20 mg Once daily *Once daily *
Symptomatic gastro-esophageal reflux20 mg Once daily for 4 weeks *Once daily for 4 weeks *
NSAID induced gastric ulcer20 mg Once daily for 4 to 8 weeks *Once daily for 4 to 8 weeks *
Zollinger-Ellison syndrome40 mg Twice dailyTwice daily
H. pylori eradication to reduce the risk of duodenal ulcer recurrence
Triple therapy:
Esomeprazole 40 mg Once daily for 10 days
Amoxicillin1000 mg Twice daily for 10 days
Clarithromycin 500 mgTwice daily for 10 days

* Depends on the severity of the disease.

Progut MUPS tablets should be swallowed whole with liquid. The tablets should not
be chewed or crushed. If required, the tablets can also be dispersed in half a glass
of non-carbonated water (mineral water is not suitable). No other liquids should be
used. Stir until the tablets disintegrate and drink the liquid with the pellets
immediately or within 30 minutes. Rinse the glass with half a glass of water and
drink. The pellets must not be chewed or crushed.


Symptomatic response to therapy with Esomeprazole does not preclude the
presence of gastric malignancy. When using in combination with antibiotic, refer to
the prescribing information of the respective antibiotics. Pediatrics patient: Safety
and effectiveness have not yet been established in pediatrics patients. Geriatric:
Dosage adjustment is not necessary. Renal insufficiency: Dosage adjustment is not
necessary. Hepatic insufficiency: Dosage adjustment is not necessary in patients
with mild to moderate liver impairment. However, in patients with severe hepatic
insufficiency, a dose of 20 mg once daily of Esomeprazole should not be exceeded.
Gender: No dosage adjustment is necessary. Use in pregnancy: This drug should be
used during pregnancy only if clearly needed. Use in lactation: As Esomeprazole is
likely to be excreted in human milk, a decision should be made whether to
discontinue the drug or nursing.

Product Details

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