Flucloxacillin is indicated for the treatment of infections due to Gram positive organisms, including infections caused by ß-lactamase producing staphylococci. Skin and soft tissue infections: Boils, abscesses, carbuncles, furunculosis, cellulitis, infected skin conditions, e.g. ulcer, eczema and acne, infected wounds, infected burns, protection for skin grafts, otitis media and externa, impetigo. Respiratory tract infections: Pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, and quinsy. Other infections caused by Flucloxacillin-sensitive organisms: Osteomyelitis, enteritis, endocarditis, urinary tract infections, meningitis, septicaemia. Flucloxacillin is also indicated for use as a prophylactic agent during major surgical procedures where appropriate; for example, cardiothoracic and orthopaedic surgery.

Dosage & Administration

Oral administration: Oral doses should be administered half to one hour before meals. Usual adult dosage (including elderly patients): 250 mg four times daily. In severe infections, dosage should be doubled.


In osteomyelitis and endocarditis: Up to 8 gm daily, in divided doses 6 to 8 hourly. In case of secondary bacterial infection in chicken pox: Flucloxacillin 500 mg six hourly should be prescribed.


Usual children dosage: 2-10 years: Half of the adult dose. Under 2 years: Quarter of the

adult dose.


Dose adjustment in renal impairment: As common with other penicillins, Flucloxacillin usage in patients with renal impairment does not usually require dosage reduction. However, in the presence of severe renal failure (creatinine clearance < 10 ml/min) a reduction in dose or an extension of dose interval should be considered. Flucloxacillin is not significantly removed by dialysis and hence no supplementary dosages need to be administered either during or at the end of the dialysis period.


Direction of Reconstitution
Flubac® powder for syrup / Flubac® DS powder for syrup: Shake the bottle well before adding water. Then add 60 ml of boiled and cool water to the bottle. For ease of preparation, add the water in two portions. Shake the bottle gently until the powder is dissolved properly. Shake the bottle before each use.


Use in pregnancy and lactation: The use of Flucloxacillin in pregnancy should be reserved for cases considered essential by the clinician. Use of the drug in the second and third trimesters may result in the sensitisation of the fetus. During lactation, trace quantities of penicillins can be detected in breast milk.

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