Dotarin® tablet: Each tablet contains 40 mg
Drotaverine Hydrochloride INN.
Drotaverine is a spasmolytic agent which acts directly on smooth muscle
cells by adsorption on the cell surface. Drotaverine inhibits the
phosphodiesterase enzyme which leads to an increase of the cAMP level
producing smooth muscle cell relaxation. It is thought that Drotaverine also
inhibits the initial calcium uptake of the cell. Drotaverine is
characterized by a rapid onset of action which is very advantageous in cases
of acute painful spastic conditions. Because of its direct action on smooth
muscle, Drotaverine does not affect the autonomic nervous system. Therefore
Drotaverine is free of the side effects associated with anticholinergic
antispasmodics and can be used in glaucoma and prostatic hypertrophy. In
addition to its spasmolytic and vasodilatory actions, Drotaverine elicits a
selective blockade of cardiac beta receptors.
Spastic conditions of the gastrointestinal tract, irritable bowel
syndrome. Biliary colics and spastic conditions of the biliary tract:
Cholecystolithiasis, cholecystitis, cholangitis. Renal colics and spastic
conditions of the urogenital tract: Nephrolithiasis, ureterolithiasis,
pyelitis, cystitis. Spastic conditions of the uterus: Dysmenorrhea, imminent
abortion, uterine tetanus.
Dotarin® tablet: Adults: 1 to 2 tablets, 3 times daily. Children (over 6
years): 1/2 to 1 tablet, 1-2 times daily. Children (1-6 years): 1/4 to 1/2
tablet, 1-2 times daily.
In rare cases nausea and vomiting may occur. Arterial blood pressure may
drop following too rapid intravenous injection. Flushing of face,
perspiration, tachycardia, hyperapnoea may be found rarely.